The prognostic implications of a tertiary component of Gleason pattern 5 cancer at radical prostatectomy remain incompletely understood. A newly published study highlights the relationship between tertiary pattern 5 cancer, other risk factors and clinical outcomes. Authors propose a prognostic model to identify patients with the greatest need for adjuvant therapy.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Bostwick, D. G. & Cheng, L. Urologic surgical pathology 3rd edn (Elsevier/Saunders, 2014).
Lucca, I. et al. Validation of tertiary Gleason pattern 5 in Gleason score 7 prostate cancer as an independent predictor of biochemical recurrence and development of a prognostic model. Urol. Oncol. http://dx.doi.org/10.1016/j.urolonc.2014.08.011.
Montironi, R. et al. Original Gleason system versus 2005 ISUP modified Gleason system: the importance of indicating which system is used in the patient's pathology and clinical reports. Eur. Urol. 58, 369–373 (2010).
Cheng, L. et al. The combined percentage of Gleason patterns 4 and 5 is the best predictor of cancer progression after radical prostatectomy. J. Clin. Oncol. 23, 2911–2917 (2005).
Jackson, W. et al. Gleason pattern 5 is the strongest pathologic predictor of recurrence, metastasis, and prostate cancer-specific death in patients receiving salvage radiation therapy following radical prostatectomy. Cancer 119, 3287–3294 (2013).
Adam, M. et al. A tertiary Gleason pattern in the prostatectomy specimen and its association with adverse outcome after radical prostatectomy. J. Urol. 192, 97–102 (2014)
Hattab, E. M., Koch, M. O., Eble, J. N., Lin, H. & Cheng, L. Tertiary Gleason pattern 5 is a powerful predictor of biochemical relapse in patients with Gleason score 7 prostatic adenocarcinoma. J. Urol. 175, 1695–1699 (2006).
Whittemore, D. E. et al. Significance of tertiary Gleason pattern 5 in Gleason score 7 radical prostatectomy specimens. J. Urol. 179, 516–522 (2008).
Sim, H. G. et al. Tertiary Gleason pattern 5 in Gleason 7 prostate cancer predicts pathological stage and biochemical recurrence. J. Urol. 179, 1775–1779 (2008).
Cheng, L., Davidson, D. D., Lin, H. & Koch, M. O. Percentage of Gleason pattern 4 and 5 predicts survival after radical prostatectomy. Cancer 110, 1967–1972 (2007).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Williamson, S., Cheng, L. Effects of tertiary Gleason pattern 5 on oncological outcome. Nat Rev Urol 12, 188–189 (2015). https://doi.org/10.1038/nrurol.2014.370
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrurol.2014.370