Bladder biopsy of normal-looking mucosa, as determined by cystoscopy, might not add clinical value in patients with positive voided-urine cytology after treatment of non-muscle-invasive bladder cancer. Methods to add value to bladder biopsies, such as characterization of molecular alterations, should be considered.
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Lopez-Beltran, A. Normal cystoscopy, malignant cytology in NMIBC: why biopsy?. Nat Rev Urol 11, 550–551 (2014). https://doi.org/10.1038/nrurol.2014.225
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DOI: https://doi.org/10.1038/nrurol.2014.225