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Routine adrenalectomy in renal cancer—an antiquated practice

For decades, complete removal of the kidney with all the contents of the Gerota's fascia (including the adrenal gland) has been a standard procedure for treating renal cell carcinoma (RCC). Two recent articles argue against routine adrenalectomy, and encourage adrenal preservation for the vast majority of patients with RCC.

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References

  1. Kutikov, A. et al. Routine adrenalectomy is unnecessary during surgery for large and/or upper pole renal tumors when the adrenal gland is radiographically normal. J. Urol. 185, 1198–1203 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Weight, C. J. et al. Routine adrenalectomy in patients with locally advanced renal cell cancer does not offer oncologic benefit and places a significant portion of patients at risk for an asynchronous metastasis in a solitary adrenal gland. Eur. Urol. 60, 458–464 (2011).

    Article  PubMed  Google Scholar 

  3. Tsui, K. H. et al. Is adrenalectomy a necessary component of radical nephrectomy? UCLA experience with 511 radical nephrectomies. J. Urol. 163, 437–441 (2000).

    Article  CAS  PubMed  Google Scholar 

  4. Robey, E. L. & Schellhammer, P. F. The adrenal gland and renal cell carcinoma: is ipsilateral adrenalectomy a necessary component of radical nephrectomy? J. Urol. 135, 453–455 (1986).

    Article  CAS  PubMed  Google Scholar 

  5. Hahner, S. et al. Epidemiology of adrenal crisis in chronic adrenal insufficiency: the need for new prevention strategies. Eur. J. Endocrinol. 162, 597–602 (2010).

    Article  CAS  Google Scholar 

  6. Bornstein, S. R. Predisposing factors for adrenal insufficiency. N. Engl. J. Med. 360, 2328–2339 (2009).

    Article  CAS  Google Scholar 

  7. Kaye, D. R. et al. Partial adrenalectomy: underused first line therapy for small adrenal tumors. J. Urol. 184, 18–25 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to W. Marston Linehan.

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Bratslavsky, G., Linehan, W. Routine adrenalectomy in renal cancer—an antiquated practice. Nat Rev Urol 8, 534–536 (2011). https://doi.org/10.1038/nrurol.2011.136

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  • DOI: https://doi.org/10.1038/nrurol.2011.136

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