Abstract
Stem cells have the ability to both differentiate into other mature cell types and maintain an undifferentiated state by self-renewal. These unique properties form the basis for stem cell use in organ replacement and tissue regeneration in clinical medicine. Currently, embryonic stem cells are the best-studied stem cell type. However alternative stem cells such as induced pluripotent stem cells and other adult stem cells are also being actively investigated for their potential for cell-based therapy. Among adult stem cells, emerging research has focused on evaluating the pluripotency potential of testis stem cells. To date, stem cells with embryonic-like potential have been created from adult testis germ cells. These cells could provide patient-specific, non-embryo-derived stem cells for men in the future.
Key Points
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A need exists for pluripotent stem cells other than human embryonic cells for cell-based therapy owing to difficulties surrounding procurement, tissue rejection and tumorigenesis with these cells
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Adult stem cells might provide an alternative source of multipotent stem cells with less rejection and decreased malignant potential than embryonic stem cells
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Testicular stem cells with multipotent and even pluripotent potential have been isolated in mouse models and, more recently, in humans
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To achieve the goal of cell-based therapy using any type of stem cell, issues of reliability and safety, in addition to efficiency and expandability, must be overcome
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P. J. Turek and R. A. Reijo Pera declare that they hold, or have applied for, patents related to testicular germline stem cells, on behalf of The Turek Clinic, San Francisco and Stanford University, CA, USA. K. Kee declares no competing interests.
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Kee, K., Reijo Pera, R. & Turek, P. Testicular germline stem cells. Nat Rev Urol 7, 94–100 (2010). https://doi.org/10.1038/nrurol.2009.263
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DOI: https://doi.org/10.1038/nrurol.2009.263
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