A new guideline from the US has neatly summarized the evidence regarding the use of 5α-reductase inhibitors for prostate disease, but falls short of providing definitive management recommendations. It will, however, be a valuable aid to both patients and physicians in the clinical decision-making process.
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References
AUA Guidelines 2009 American Urological Association [online] (2009).
EAU Guidelines 2009 European Association of Urology [online] (2009).
McConnell, J. D. et al. The long-term effect of doxazocin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia. N. Engl. J. Med. 349, 2387–2398 (2003).
Klotz, L. & Clarke, N. W. Open to debate. The Motion: all men over the age of 50 should be encouraged to take a 5α-reductase inhibitor to prevent prostate cancer. Eur. Urol. 53, 1079–1083 (2008).
Kramer, B. S. et al. Use of 5α-reductase inhibitors for prostate cancer chemoprevention: American Society of Clinical Oncology/American Urological Association 2008 Clinical Practice Guideline. J. Urol. 181, 1642–1647 (2009).
Kramer, B. S. et al. Use of 5α-reductase inhibitors for prostate cancer chemoprevention: American Society of Clinical Oncology/American Urological Association 2008 Clinical Practice Guideline. J. Clin. Oncol. 27, 1502–1516 (2009).
Thompson, I. M. et al. The influence of finasteride on the development of prostate cancer. N. Engl. J. Med. 349, 215–224 (2003).
Schröder, F. H. et al. Screening and prostate-cancer mortality in a randomized European study. N. Engl. J. Med. 360, 1320–1328 (2009).
Andriole G. L. et al. Mortality results from a randomized prostate-cancer screening trial. N. Engl. J. Med. 360, 1310–1319 (2009).
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Clarke, N. Should 5α-reductase inhibitors be used for prostate disease?. Nat Rev Urol 6, 358–359 (2009). https://doi.org/10.1038/nrurol.2009.105
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DOI: https://doi.org/10.1038/nrurol.2009.105