In women with systemic lupus erythematosus followed in the Hopkins Lupus Cohort (1987–2015), the incidence of disease flare increased during pregnancy (HR 1.59; 95% CI 1.27–1.96) and within the 3 months after delivery (HR 1.48; 95% CI 1.07–1.95), compared with non-pregnant, non-postpartum periods. The risk of flare during pregnancy was lower in patients treated with hydroxychloroquine (HR 1.26; 95% CI 0.88–1.69) than in those who were not (HR 1.83; 95% CI 1.34–2.45).
References
Eudy, A. M. et al. Effect of pregnancy on disease flares in patients with systemic lupus erythematosus. Ann. Rheum. Dis. https://doi.org/10.1136/annrheumdis-2017-212535 (2018)
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Onuora, S. Incidence of flare is increased in pregnancy. Nat Rev Rheumatol 14, 248 (2018). https://doi.org/10.1038/nrrheum.2018.45
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DOI: https://doi.org/10.1038/nrrheum.2018.45
