TNF inhibition is associated with an increased risk of lymphoma development. But is this association due to the TNF inhibitors themselves or the patient's underlying disease?
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References
Her, M. & Kavanaugh, A. Advances in use of immunomodulatory agents — a rheumatology perspective. Nat. Rev. Gastroenterol. Hepatol. 12, 363–368 (2015).
Kalliolias, G. D. & Ivashkiv, L. B. TNF biology, pathogenic mechanisms and emerging therapeutic strategies. Nat. Rev. Rheumatol. 12, 49–62 (2016).
Dixon, W. G. et al. Influence of anti-tumor necrosis factor therapy on cancer incidence in patients with rheumatoid arthritis who have had a prior malignancy: results from the British Society for Rheumatology Biologics Register. Arthritis Care Res. (Hoboken) 62, 755–763 (2010).
Baecklund, E. et al. Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis. Arthritis Rheum. 54, 692–671 (2006).
Singh, J. A. et al. 2015 American College of Rheumatology guideline for the treatment of rheumatoid arthritis. Arthritis Rheumatol. 68, 1–26 (2016).
Mercer, L. K. et al. Risk of lymphoma in patients exposed to antitumour necrosis factor therapy: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis. Ann. Rheum. Dis. 76, 497–503 (2017).
Mercer, L. K. et al. Spectrum of lymphomas across different drug treatment groups in rheumatoid arthritis: a European registries collaborative project. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2017-211623 (2017).
Acknowledgements
The research of A.K is supported in part by the Phil and Amy Mickelson Charitable Foundation
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Kavanaugh, A. Do TNF inhibitors influence lymphoma development?. Nat Rev Rheumatol 13, 697–698 (2017). https://doi.org/10.1038/nrrheum.2017.186
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DOI: https://doi.org/10.1038/nrrheum.2017.186