Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Autoimmunity

Regulatory B cells—IL-35 and IL-21 regulate the regulators

Nature Reviews Rheumatology volume 10, pages 452–453 (2014)Cite this article

Subjects

A Correction to this article was published on 16 September 2014

This article has been updated

IL-21 regulates the activity and number of IL-10-producing regulatory B cells (B10 cells) that modulate immune responses and limit diverse autoimmune diseases. A new study demonstrates that IL-35 has a similar function. Identifying regulatory circuits that control B10-cell function in vivo might open the door to future treatments for autoimmune diseases.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: IL-12 cytokine family signalling.

Change history

  • 16 September 2014

    In the original version of this article, the IL-12 and IL-23 receptors were incorrectly labelled. This error has now been corrected in the HTML and PDF versions of the article.

References

  1. Kalampokis, I., Yoshizaki, A. & Tedder, T. F. IL-10-producing regulatory B cells (B10 cells) in autoimmune disease. Arthritis Res. Ther. 15 (Suppl. 1), S1 (2013).

    Article  Google Scholar 

  2. Banchereau, J., Pascual, V. & O'Garra, A. From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines. Nat. Immunol. 13, 925–931 (2012).

    Article  CAS  Google Scholar 

  3. Wang, R. X. et al. Interleukin-35 induces regulatory B cells that suppress autoimmune disease. Nat. Med. http://dx.doi.org/10.1038/nm.3554 (2014).

  4. Yoshizaki, A. et al. Regulatory B cells control T cell autoimmunity through IL-21-dependent cognate interactions. Nature 491, 264–268 (2012).

    Article  CAS  Google Scholar 

  5. Spolski, R. & Leonard, W. J. Interleukin-21: a double-edged sword with therapeutic potential. Nat. Rev. Drug Discov. 13, 379–395 (2014).

    Article  CAS  Google Scholar 

  6. Vignali, D. A. & Kuchroo, V. K. IL-12 family cytokines: immunological playmakers. Nat. Immunol. 13, 722–728 (2012).

    Article  CAS  Google Scholar 

  7. Collison, L. W. et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 450, 566–569 (2007).

    Article  CAS  Google Scholar 

  8. Niedbala, W. et al. IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of TH17 cells. Eur. J. Immunol. 37, 3021–3029 (2007).

    Article  CAS  Google Scholar 

  9. Collison, L. W. et al. The composition and signaling of the IL-35 receptor are unconventional. Nat. Immunol. 13, 290–299 (2012).

    Article  CAS  Google Scholar 

  10. Shen, P. et al. IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases. Nature 507, 366–370 (2014).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors are supported by the Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH.

Author information

Authors and Affiliations

  1. Department of Immunology, Duke University Medical Center, Durham, 27710, NC, USA

    Thomas F. Tedder

  2. Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, 208921674, MD, USA

    Warren J. Leonard

Authors
  1. Thomas F. Tedder
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Warren J. Leonard
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Thomas F. Tedder.

Ethics declarations

Competing interests

T.F.T is an inventor on Duke University patents relating to B10 cells. W.J.L. is an inventor on NIH patents relating to IL-21.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tedder, T., Leonard, W. Regulatory B cells—IL-35 and IL-21 regulate the regulators. Nat Rev Rheumatol 10, 452–453 (2014). https://doi.org/10.1038/nrrheum.2014.95

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrrheum.2014.95

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing