Even though activation of immunity is associated with bone destruction, new mechanisms have been described in 2014 through which immunology-associated pathways can cooperate to support osteogenesis. These advances support the view of the immune system as a central mechanism which can regulate bone homeostasis, regeneration and destruction.
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The author would like to thank Noriko Komatsu, The University of Tokyo, Japan and Tomoki Nakashima, Tokyo Medical and Dental University, Japan for discussion and assistance.
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Takayanagi, H. Two-faced immunology—from osteogenesis to bone resorption. Nat Rev Rheumatol 11, 74–76 (2015). https://doi.org/10.1038/nrrheum.2014.219
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DOI: https://doi.org/10.1038/nrrheum.2014.219
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