Macrophages have important roles in the induction and resolution of inflammation, but the intracellular pathways from inflammatory signals to pain response remain unclear. A recent study demonstrates that the P2X4 receptor mediates inflammatory pain by inducing formation of the potent lipid mediator prostaglandin E2.
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Per-Johan Jakobsson is a member of the board and patent holder of NovaSAID AB.
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Jakobsson, PJ. How macrophages mediate inflammatory pain via ATP signaling. Nat Rev Rheumatol 6, 679–681 (2010). https://doi.org/10.1038/nrrheum.2010.175
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DOI: https://doi.org/10.1038/nrrheum.2010.175
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