To date, understanding of the molecular mechanisms of bone metabolism has centered on three tumor necrosis factor family members—RANK, its ligand RANKL and its decoy receptor osteoprotegrin. This view should now be modified, however, to incorporate the role of interferon regulatory factor-8.
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Wagner, H. Interferon regulatory factor-8 suppresses osteoclastogenesis. Nat Rev Rheumatol 6, 73–74 (2010). https://doi.org/10.1038/nrrheum.2009.274
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DOI: https://doi.org/10.1038/nrrheum.2009.274
