Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Bone

Serotonin, leptin and the central control of bone remodeling

Nature Reviews Rheumatology volume 5, pages 657–658 (2009)Cite this article

Researchers have identified a new molecular pathway for the regulation of bone and energy metabolism that challenges the conventional view of the role of leptin in bone turnover.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The metabolic–skeletal connection.

References

  1. Yadav, V. K. et al. A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell 138, 976–989 (2009).

    Article  CAS  Google Scholar 

  2. Forbes, A. P. Fuller Albright: his concept of postmenopausal osteoporosis and what came of it. Clin. Orthop. Relat. Res. 269, 128–141 (1991).

    Google Scholar 

  3. Ettinger, B. et al. Associations between low levels of serum estradiol, bone density, and fractures among elderly women: the study of osteoporotic fractures. J. Clin. Endocrinol. Metab. 83, 2239–2243 (1998).

    CAS  PubMed  Google Scholar 

  4. Weng, M. Y. & Lane, N. E. Medication-induced osteoporosis. Curr. Osteoporos. Rep. 4, 139–145 (2007).

    Article  Google Scholar 

  5. Ducy, P. et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100, 197–207 (2000).

    Article  CAS  Google Scholar 

  6. Ferron, M., Hinoi, E., Karsenty, G. & Ducy, P. Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc. Natl Acad. Sci. USA 105, 5266–5270 (2008).

    CAS  PubMed  Google Scholar 

  7. Adachi, J. D. Glucocorticoid-induced osteoporosis. Osteoporos. Int. 20 (Suppl. 3), 239–240 (2009).

    Article  Google Scholar 

  8. Rosen, C. J. Serotonin rising—the bone–brain–bowel connection. N. Engl. J. Med. 360, 957–959 (2009).

    Article  CAS  Google Scholar 

  9. Warden, S. J., Robling, A. G., Sanders, M. S., Bliziotes, M. M. & Turner, C. H. Inhibition of the serotonin (5-hydroxytryptamine) transporter reduces bone accrual during growth. Endocrinology 146, 685–693 (2005).

    Article  CAS  Google Scholar 

  10. Yadav, V. K. et al. Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell 135, 825–837 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Maine Medical Center Research Institute, Scarborough, ME, USA

    Clifford J. Rosen

Authors
  1. Clifford J. Rosen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Clifford J. Rosen.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rosen, C. Serotonin, leptin and the central control of bone remodeling. Nat Rev Rheumatol 5, 657–658 (2009). https://doi.org/10.1038/nrrheum.2009.231

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrrheum.2009.231

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing