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Inflammation

Canakinumab for the cryopyrin-associated periodic syndromes

Biologic therapies that target interleukin (IL)-1 are known to dramatically improve symptoms of a group of rare, heritable chronic inflammatory diseases. The results of a phase III trial confirm the place of canakinumab in the treatment arsenal for these disorders.

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References

  1. Mathews, R. J., Sprakes, M. & McDermott, M. F. Nod-like receptors and inflammation. Arthritis Res. Ther. 10, 228 (2008).

  2. Agostini, L. et al. NALP3 forms an Il-1β-processing inflammasome with increased activity in Muckle–Wells autoinflammatory disorder. Immunity 30, 319–325 (2004).

    Article  Google Scholar 

  3. Mansky-Goldbach, R. et al. Neonatal-onset multisystem inflammatory disease responsive to interleukin-1β inhibition. N. Engl. J. Med. 355, 581–592 (2006).

    Article  Google Scholar 

  4. Lachmann, H. J. et al. Use of canakinumab in the cryopyrin-associated periodic syndrome. N. Engl. J. Med. 360, 2416–2425 (2009).

    Article  CAS  Google Scholar 

  5. Lachmann, H. J. et al. In vivo regulation of interleukin 1β in patients with cryopyrin-associated periodic syndromes. J. Exp. Med. 206, 1029–1036 (2009).

    Article  CAS  Google Scholar 

  6. Hoffman, H. M. et al. Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies. Arthritis Rheum. 58, 2443–2452 (2008).

    Article  CAS  Google Scholar 

  7. Ruperto, N. et al. A phase II trial with canakinumab (ACZ885), A new IL-1β blocking monoclonal antibody to evaluate the safety and preliminary efficacy in children with systemic juvenile idiopathic arthritis [abstract OP-0298]. Arthritis Rheum. 68 (Suppl. 3), 170–171 (2009).

    Google Scholar 

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Correspondence to Michael F. McDermott.

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S. Savic and M. F. McDermott have acted as consultants for Novartis Pharma.

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Savic, S., McDermott, M. Canakinumab for the cryopyrin-associated periodic syndromes. Nat Rev Rheumatol 5, 529–530 (2009). https://doi.org/10.1038/nrrheum.2009.195

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