What is the relationship between genetic and environmental risk factors in predisposing for rheumatoid arthritis (RA)? A new study provides more details on the interaction between the HLA DRB1 shared epitope (SE) alleles and smoking in conferring the risk of autoantibody-positive RA.
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van der Woude, D., Huizinga, T. Every shared epitope allele for itself?. Nat Rev Rheumatol 5, 477–478 (2009). https://doi.org/10.1038/nrrheum.2009.174
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DOI: https://doi.org/10.1038/nrrheum.2009.174
