A variant in the TNFSF13B gene that encodes B-cell-activating factor has been found to increase the risk of multiple sclerosis and systemic lupus erythematosus in the Sardinian population. The findings underscore, and offer new insight into, the role of B cells in these autoimmune disorders, and have implications for personalized therapy.
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Comabella, M. B cells and variant BAFF in autoimmune disease. Nat Rev Neurol 13, 453–454 (2017). https://doi.org/10.1038/nrneurol.2017.87
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DOI: https://doi.org/10.1038/nrneurol.2017.87
