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Parkinson disease

What goes around comes around: cognitive impairment as prodromal parkinsonism?

Nature Reviews Neurology volume 13, pages 709–710 (2017)Cite this article

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Patients with prodromal Parkinson disease (PD) are most likely to respond to disease-modifying strategies. To date, cognitive impairment has been viewed as a complication of late-stage disease, but a longitudinal analysis of data from the Rotterdam cohort raises the possibility that such impairments are also associated with prodromal PD.

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References

  1. Aarsland, D. et al. Cognitive decline in Parkinson disease. Nat. Rev. Neurol. 13, 217–231 (2017).

    Article  Google Scholar 

  2. Berg, D. et al. MDS research criteria for prodromal Parkinson's disease. Mov. Disord. 30, 1600–1611 (2015).

    Article  Google Scholar 

  3. Athauda, D. & Foltynie, T. Challenges in detecting disease modification in Parkinson's disease clinical trials. Parkinsonism Relat. Disord. 32, 1–11 (2016).

    Article  Google Scholar 

  4. Darweesh, S. K. L. et al. Association between poor cognitive functioning and risk of incident parkinsonism: the Rotterdam study. JAMA Neurol. http://dx.doi.org/10.1001/jamaneurol.2017.2248 (2017).

  5. Iranzo, A. et al. Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study. Lancet Neurol. 9, 1070–1077 (2010).

    Article  CAS  Google Scholar 

  6. Braak, H. et al. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol. Aging. 24, 197–211 (2003).

    Article  Google Scholar 

  7. Postuma, R. B. et al. MDS clinical diagnostic criteria for Parkinson's disease. Mov. Disord. 30, 1591–1601 (2015).

    Article  Google Scholar 

  8. Compta, Y. et al. Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important? Brain 134, 1493–1505 (2011).

    Article  Google Scholar 

  9. Parkinson Progression Marker Initiative. The Parkinson Progression Marker Initiative (PPMI). Prog. Neurobiol. 95, 629–635 (2011).

  10. Noyce, A. J. et al. PREDICT-PD: identifying risk of Parkinson's disease in the community: methods and baseline results. J. Neurol. Neurosurg. Psychiatry 85, 31–37 (2014).

    Article  Google Scholar 

Download references

Acknowledgements

Y.C. and M.J.M. gratefully acknowledge financial support from the CERCA Programme of the Generalitat de Catalunya (Barcelona, Catalonia, Spain).

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Authors and Affiliations

  1. Yaroslau Compta is at the Parkinson's Disease and Movement Disorders Unit of the Neurology Service of Hospital Clinic/IDIBAPS/CIBERNED; and at the Department of Biomedicine of the University of Barcelona, 170 Villarroel, 08036, Barcelona, Catalonia, Spain.,

    Yaroslau Compta

  2. and at the Department of Biomedicine of the University of Barcelona, 170 Villarroel, 08036, Barcelona, Catalonia, Spain.,

    Yaroslau Compta

  3. Maria J. Martí is at the Parkinson's Disease and Movement Disorders Unit of the Neurology Service of Hospital Clinic/IDIBAPS/CIBERNED; and at the Department of Medicine of the University of Barcelona, 170 Villarroel, 08036, Barcelona, Catalonia, Spain.,

    Maria J. Martí

  4. and at the Department of Medicine of the University of Barcelona, 170 Villarroel, 08036, Barcelona, Catalonia, Spain.,

    Maria J. Martí

Authors
  1. Yaroslau Compta
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  2. Maria J. Martí
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Correspondence to Maria J. Martí.

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The authors declare no competing financial interests.

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Compta, Y., Martí, M. What goes around comes around: cognitive impairment as prodromal parkinsonism?. Nat Rev Neurol 13, 709–710 (2017). https://doi.org/10.1038/nrneurol.2017.159

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