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Alzheimer disease

Host immune defence, amyloid-β peptide and Alzheimer disease

Nature Reviews Neurology volume 12, pages 433–434 (2016)Cite this article

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A recent study demonstrates that amyloid-β (Aβ) can function as an antimicrobial peptide, and additional data show that bacteria and yeast can seed Aβ deposition into amyloid. These data suggest a complex interplay between the normal function of Aβ, its accumulation in the brain, and host immune defence.

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Figure 1: Antimicrobial peptide activity of amyloid-β.

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Authors and Affiliations

  1. Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, McKnight Brian Institute, College of Medicine, University of Florida, 1275 Center Drive, BMS J-497, Gainesville, 32610, Florida, USA

    Todd E. Golde

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  1. Todd E. Golde
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Correspondence to Todd E. Golde.

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The author declares no competing financial interests.

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Golde, T. Host immune defence, amyloid-β peptide and Alzheimer disease. Nat Rev Neurol 12, 433–434 (2016). https://doi.org/10.1038/nrneurol.2016.105

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