Diagnosis and management of epilepsy remain challenging, particularly among women of child-bearing age. In 2015, notable steps were taken in the right direction, with work that provided insight into the diagnosis of epilepsy, management of this condition during pregnancy, and new treatment options.
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Anti-high mobility group box protein 1 monoclonal antibody downregulating P-glycoprotein as novel epilepsy therapeutics
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Open Access 22 October 2022
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References
de Boer, H. M., Mula, M. & Sander, J. W. The global burden and stigma of epilepsy. Epilepsy Behav. 12, 540–546 (2008).
Firkin, A. L. et al. Mind the gap: multiple events and lengthy delays before presentation with a 'first seizure'. Epilepsia 56, 1534–1541 (2015).
Marson, A. G. et al. The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial. Lancet 369, 1016–1026 (2007).
Campbell, E. et al. Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers. J. Neurol. Neurosurg. Psychiatry 85, 1029–1034 (2014).
Bromley, R. et al. Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child. Cochrane Database Syst. Rev. 10, CD010236 (2014).
Baker, G. A. et al. IQ at 6 years after in utero exposure to antiepileptic drugs: a controlled cohort study. Neurology 84, 382–390 (2015).
Meador, K. J. et al. Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study. Lancet Neurol. 12, 244–252 (2013).
Tomson, T. et al. Dose-dependent teratogenicity of valproate in mono- and polytherapy: an observational study. Neurology 85, 866–872 (2015).
French, J. A. et al. Perampanel for tonic–clonic seizures in idiopathic generalized epilepsy: a randomized trial. Neurology 85, 950–957 (2015).
van Loo, K. M. et al. Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1. Nat. Commun. 6, 8688 (2015).
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Elger, C. Classic antiepileptic drugs under fire, and new options emerge. Nat Rev Neurol 12, 72–74 (2016). https://doi.org/10.1038/nrneurol.2016.1
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DOI: https://doi.org/10.1038/nrneurol.2016.1
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Anti-high mobility group box protein 1 monoclonal antibody downregulating P-glycoprotein as novel epilepsy therapeutics
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery (2022)