Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Year in Review
  • Published:

Stroke in 2015

Acute endovascular recanalization therapy comes of age

Subjects

The past year has seen practice-changing findings in stroke research. Strong evidence now supports endovascular thrombectomy as the new gold standard of care in acute ischaemic stroke, and a pragmatic trial raised concerns over early intensive mobilization after stroke. Moreover, new insights were gained into the trajectory of stroke-associated cognitive decline.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Gold-standard treatment of acute ischaemic stroke.

References

  1. Berkhemer, O. A. et al. A randomized trial of intraarterial treatment for acute ischemic stroke. N. Engl. J. Med. 372, 11–20 (2015).

    Article  Google Scholar 

  2. Goyal, M. et al. Randomized assessment of rapid endovascular treatment of ischemic stroke. N. Engl. J. Med. 372, 1019–1030 (2015).

    Article  CAS  Google Scholar 

  3. Campbell, B. C. et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N. Engl. J. Med. 372, 1009–1018 (2015).

    Article  CAS  Google Scholar 

  4. Saver, J. L. et al. Stent-retriever thrombectomy after intravenous t-PA versus t-PA alone in stroke. N. Engl. J. Med. 372, 2285–2295 (2015).

    Article  CAS  Google Scholar 

  5. Jovin, T. G. et al. Thrombectomy within 8 hours after symptom onset in ischemic stroke. N. Engl. J. Med. 372, 2296–2306 (2015).

    Article  CAS  Google Scholar 

  6. Powers, W. J. et al. American Heart Association/American Stroke Association focused update of the 2013 guidelines for the early management of patients with acute ischemic stroke regarding endovascular treatment: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 46, 3020–3035 (2015).

    Article  CAS  Google Scholar 

  7. Bernhardt, J., English, C., Johnson, L. & Cumming, T. B. Early mobilization after stroke: early adoption but limited evidence. Stroke 46, 1141–1146 (2015).

    Article  Google Scholar 

  8. Bernhardt, J. et al. Efficacy and safety of very early mobilisation within 24 h of stroke onset (AVERT): a randomised controlled trial. Lancet 386, 46–55 (2015).

    Article  Google Scholar 

  9. Gorelick, P. B. et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 42, 2672–2713 (2011).

    Article  Google Scholar 

  10. Levine, D. A. et al. Trajectory of cognitive decline after incident stroke. JAMA 314, 41–51 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Alejandro A. Rabinstein.

Ethics declarations

Competing interests

The author declares no competing financial interests.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rabinstein, A. Acute endovascular recanalization therapy comes of age. Nat Rev Neurol 12, 67–68 (2016). https://doi.org/10.1038/nrneurol.2015.241

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneurol.2015.241

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing