Since 2005, we have made substantial progress in understanding the pathophysiology and natural history of movement disorders such as Parkinson disease and Huntington disease. However, disease-modifying therapies for these conditions have proved elusive and, as a consequence, treatments remain largely symptomatic.
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References
Suchowersky, O. et al. Practice parameter: diagnosis and prognosis of new onset Parkinson disease (an evidence-based review). Neurology 66, 968–975 (2006).
Tolosa, E., Gaig, C., Santamaria, J. & Compta, Y. Diagnosis and the premotor phase of Parkinson disease. Neurology 72 (Suppl. 2), S12–S20 (2009).
Barone, P. et al. The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease. Mov. Disord. 24, 1641–1649 (2009).
den Brok, M. G. et al. Apathy in Parkinson's disease: a systematic review and meta-analysis. Mov. Disord. 30, 759–769 (2015).
Van der Brug, M. P., Singleton, A, Gasser, T. & Lewis, P. A. Parkinson's disease: from human genetics to clinical trials. Sci. Transl. Med. 7, 305ps20 (2015).
Writing Group for the NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators et al. Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial. JAMA 313, 584–593 (2015).
Tabrizi, S. J. et al. Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data. Lancet Neurol. 12, 637–649 (2013).
Stanek, L. M. et al. Silencing mutant huntingtin by adeno-associated virus-mediated RNA interference ameliorates disease manifestations in the YAC128 mouse model of Huntington's disease. Hum. Gene Ther. 25, 461–474 (2014).
Leen, W. G. et al. Glucose transporter-1 deficiency syndrome: the expanding clinical and genetic spectrum of a treatable disorder. Brain 133, 655–670 (2010).
Bigi, S., Hldio, M., Twilt, M., Dalmau, J. & Benseler, S. M. The growing spectrum of antibody-associated inflammatory brain diseases in children. Neurol. Neuroimmunol. Neuroinflamm. 2, e92 (2015).
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The author has received research grants from AbbVie and Biotie. She has received honoraria from AbbVie, Allergan and Merz.
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Suchowersky, O. Tracking the pathogenesis of movement disorders. Nat Rev Neurol 11, 618–619 (2015). https://doi.org/10.1038/nrneurol.2015.201
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DOI: https://doi.org/10.1038/nrneurol.2015.201
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