In my personal view, the past decade in dementia research has been marked by remarkable discoveries in the field of frontotemporal dementia, accompanied by steady scientific consolidation tinged with therapeutic disappointments related to Alzheimer disease.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Change history
04 November 2015
In the version of this article initially published online, the phrase "the last big piece" was incorrectly written as "the last piece big" in the first sentence of the third paragraph. The error has been corrected for the print and online versions of the article.
References
Baker, M. et al. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature 442, 916–919 (2006).
Neumann, M. et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 314, 130–133 (2006).
Renton, A. E. et al. A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS–FTD. Neuron 72, 257–268 (2011).
DeJesus-Hernandez, M. et al. Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron 72, 245–256 (2011).
Rascovsky, K. et al. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 134, 2456–2477 (2011).
Gorno-Tempini, M. L. et al. Classification of primary progressive aphasia and its variants. Neurology 76, 1006–1014 (2011).
Clavaguera, F. et al. Transmission and spreading of tauopathy in transgenic mouse brain. Nat. Cell Biol. 11, 909–913 (2009).
Bateman, R. J. et al. Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N. Engl. J. Med. 367, 795–804 (2012).
Holmes, C. et al. Long-term effects of Aβ42 immunisation in Alzheimers disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet 372, 216–223 (2008).
Buckner, R. L. et al. Molecular, structural, and functional characterization of Alzheimers disease: evidence for a relationship between default activity, amyloid, and memory. J. Neurosci. 25, 7709–7717 (2005).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Hodges, J. A decade of discovery and disappointment in dementia research. Nat Rev Neurol 11, 613–614 (2015). https://doi.org/10.1038/nrneurol.2015.191
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneurol.2015.191
