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Dementia

Vascular and neurodegenerative pathways—will they meet?

Nature Reviews Neurology volume 9, pages 487–488 (2013)Cite this article

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Vascular and neurodegenerative pathologies are known to co-occur in Alzheimer disease, and were recently proposed to drive progression to dementia through independent pathways. A new study provides evidence in support of this hypothesis, by showing dissociation between the pathologies and regional brain metabolism. But might the two pathways converge?

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Figure 1: Vascular and neurodegenerative pathways to dementia.

References

  1. Garde, E., Mortensen, E. L., Krabbe, K., Rostrup, E. & Larsson, H. B. Relation between age-related decline in intelligence and cerebral white-matter hyperintensities in healthy octogenarians: a longitudinal study. Lancet 356, 628–634 (2000).

    Article  CAS  PubMed  Google Scholar 

  2. Inzitari, D. et al. Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort. BMJ 339, b2477 (2009).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Kalaria, R. N., Akinyemi, R. & Ihara, M. Does vascular pathology contribute to Alzheimer changes? J. Neurol. Sci. 322, 141–147 (2012).

    Article  CAS  PubMed  Google Scholar 

  4. Haight, T. J. et al. Dissociable effects of Alzheimer disease and white matter hyperintensities on brain metabolism. JAMA Neurol. http://dx.doi.org/10.1001/jamaneurol.2013.1878.

  5. Ihara, M. et al. Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer's disease, and dementia with Lewy bodies. Acta Neuropathol. 119, 578–589 (2010).

    Article  Google Scholar 

  6. Tullberg, M. et al. White matter lesions impair frontal lobe function regardless of their location. Neurology 63, 246–253 (2004).

    CAS  PubMed  Google Scholar 

  7. Kalaria, R. N. The role of cerebral ischemia in Alzheimer's disease. Neurobiol. Aging 21, 321–330 (2000).

    Article  CAS  PubMed  Google Scholar 

  8. Firbank, M. J. et al. Neuroimaging predictors of death and dementia in a cohort of older stroke survivors. J. Neurol. Neurosurg. Psychiatry 83, 263–267 (2011).

    Article  PubMed  Google Scholar 

  9. Boyle, P. A. et al. Much of late life cognitive decline is not due to common neurodegenerative pathologies. Ann. Neurol. http://dx.doi.org/10.1002/ana.23964.

  10. de Leeuw, F. E., Barkhof, F. & Scheltens, P. White matter lesions and hippocampal atrophy in Alzheimer's disease. Neurology 62, 310–312 (2004).

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The authors are supported by Alzheimer's Research UK, the Newcastle National Institute for Health Research Biomedical Research Centre in Ageing and Age Related Diseases, Newcastle upon Tyne Hospitals, NHS Foundation Trust, and the RCUK Newcastle Centre for Brain Ageing and Vitality, Medical Research Council (UK).

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Authors and Affiliations

  1. Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK

    Raj N. Kalaria

  2. Department of Stroke and Cerebrovascular Diseases, National Cerebral and Cardiovascular Centre, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan

    Masafumi Ihara

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  1. Raj N. Kalaria
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Correspondence to Raj N. Kalaria.

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Kalaria, R., Ihara, M. Vascular and neurodegenerative pathways—will they meet?. Nat Rev Neurol 9, 487–488 (2013). https://doi.org/10.1038/nrneurol.2013.164

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