Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Stroke

Initial stroke volume is an independent outcome predictor

A new study suggests that lesion volume assessed within 72 h of stroke onset is an important independent predictor of 90-day functional outcome and neurological recovery. If used in stroke trials, outcome models including stroke volume, age and NIH Stroke Scale scores could increase power for detecting treatment effect.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Vogt, G., Laage, R., Shuaib, A. & Schneider, A. Initial lesion volume is an independent predictor of clinical Stroke outcome at day 90: an analysis of the Virtual International Stroke Trials Archive (VISTA) database. Stroke 43, 1266–1272 (2012).

    Article  Google Scholar 

  2. Konig, I. R. et al. Predicting long-term outcome after acute ischemic stroke: a simple index works in patients from controlled clinical trials. Stroke 39, 1821–1826 (2008).

    Article  Google Scholar 

  3. Johnston, K. C. et al. Validation of an acute ischemic stroke model: does diffusion-weighted imaging lesion volume offer a clinically significant improvement in prediction of outcome? Stroke 38, 1820–1825 (2007).

    Article  Google Scholar 

  4. Hand, P. J. et al. MR diffusion-weighted imaging and outcome prediction after ischemic stroke. Neurology 66, 1159–1163 (2006).

    Article  CAS  Google Scholar 

  5. Yoo, A. J. et al. Combining acute diffusion-weighted imaging and mean transmit time lesion volumes with National Institutes of Health Stroke Scale Score improves the prediction of acute stroke outcome. Stroke 41, 1728–1735 (2010).

    Article  Google Scholar 

  6. Baird, A. E. et al. A three-item scale for the early prediction of stroke recovery. Lancet 357, 2095–2099 (2001).

    Article  CAS  Google Scholar 

  7. Weimar, C., Ziegler, A., Konig, I. R. & Diener, H. C. Predicting functional outcome and survival after acute ischemic stroke. J. Neurol. 249, 888–895 (2002).

    Article  Google Scholar 

  8. German Stroke Study Collaboration. Predicting outcome after acute ischemic stroke: an external validation of prognostic models. Neurology 62, 581–585 (2004).

    Article  Google Scholar 

Download references

Acknowledgements

C. Weimar is a member of the Virtual International Stroke Trials Archive (VISTA) steering committee.

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Weimar, C. Initial stroke volume is an independent outcome predictor. Nat Rev Neurol 8, 305–306 (2012). https://doi.org/10.1038/nrneurol.2012.91

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneurol.2012.91

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing