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Alzheimer disease

Biomarker trajectories across stages of Alzheimer disease

Alzheimer disease features neurobiological changes long before the first symptoms of cognitive decline. Results from a new study to define the orderly changes of markers of amyloidosis and neurodegeneration over the disease course will assist the development of biomarker-based protocols for early diagnosis, and disease-modifying drugs.

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Figure 1: Profiles of biomarkers throughout the time course of AD.

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Frisoni, G. Biomarker trajectories across stages of Alzheimer disease. Nat Rev Neurol 8, 299–300 (2012). https://doi.org/10.1038/nrneurol.2012.81

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