Understanding how genetic variation can confer susceptibility to neurological disease is an urgent priority. A new gene-expression study has explored the relationship between DNA sequence variation at the microtubule-associated protein tau (MAPT) locus and MAPT expression in the brain, providing an exciting new paradigm for the field.
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Acknowledgements
Work in the Wade-Martins laboratory has been supported by Alzheimer's Research UK, Cure PSP, The Wellcome Trust and the Monument Trust Discovery Award from Parkinson's UK.
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Wade-Martins, R. The MAPT locus—a genetic paradigm in disease susceptibility. Nat Rev Neurol 8, 477–478 (2012). https://doi.org/10.1038/nrneurol.2012.169
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DOI: https://doi.org/10.1038/nrneurol.2012.169
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