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Epilepsy

Update to guidelines on treatment of infantile spasms

Nature Reviews Neurology volume 8, pages 480–482 (2012)Cite this article

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An evidence-based update to the 2004 guidelines for the treatment of infantile spasms has recently been published. Important new recommendations include use of low-dose adrenocorticotropic hormone (ACTH) over high-dose ACTH or vigabatrin. A paucity of data, however, leaves several key questions unanswered.

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References

  1. Riikonen, R. in Long-term Evolution of Epileptic Encephalopathies (eds Nikanorova, M. et al.) 13–28 (John Libbey Eurotext, Esher, 2009).

    Google Scholar 

  2. Go, C. et al. Evidence-based guideline update: medical treatment of infantile spasms. Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology 78, 1974–1980 (2012).

    Article  CAS  PubMed Central  Google Scholar 

  3. Mackay, M. T. et al. Practice parameter: medical treatment of infantile spasms: report of American Academy of Neurology and Child Neurology Society. Neurology 62, 1668–1681 (2004).

    Article  CAS  PubMed Central  Google Scholar 

  4. Lux, A. L. et al. The United Kingdom Infantile Spasms Study comparing vigabatrin with prednisolone or tetracosactide at 14 days: a multicentre, randomized controlled trial. Lancet 364, 1773–1778 (2004).

    Article  CAS  PubMed Central  Google Scholar 

  5. Riikonen, R. Long-term outcome of patients with West syndrome. Brain Dev. 23, 683–687 (2001).

    Article  CAS  PubMed Central  Google Scholar 

  6. Darke, K. et al. Developmental and epilepsy outcomes at age 4 years in the UKISS trial comparing hormonal treatments to vigabatrin for infantile spasms: a multicentre randomized trial. Arch. Dis. Child. 95, 382–386 (2010).

    Article  PubMed Central  Google Scholar 

  7. Riikonen, R., Jääskeläinen, J. & Turpeinen, U. Insulin-like growth factor-1 is associated with cognitive outcome in infantile spasms. Epilepsia 51, 1283–1289 (2010).

    Article  CAS  PubMed Central  Google Scholar 

  8. Bittigau, P. Sifringer, M. & Ikonomidou, C. Antiepileptic drugs and apoptosis in the developing brain. Ann. NY Acad. Sci. 993, 103–114 (2003).

    Article  CAS  PubMed Central  Google Scholar 

  9. Moskowitz, A., Hansen, R. M., Eklund, S. E. & Fulton, A. B. Electroretinographic (ERG) responses in pediatric patients using vigabatrin. Doc. Ophthalmol. 124, 197–209 (2012).

    Article  PubMed Central  Google Scholar 

  10. Riikonen, R. Does vigabatrin treatment for infantile spasms bring visual field defects? Presented at the Joint 12th International Child Neurology Congress and 11th Asian and Oceanian Congress of Child Neurology, http://icnapedia.org/lectures/53-icnc2012/sig-meetings/2484-vigabatrin-visual-field-defects (2012).

    Google Scholar 

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Authors and Affiliations

  1. Department of Child Neurology, University of Eastern Finland, Puijonlaaksontie 2, PO Box 1627, FI-70211, Kuopio, Finland

    Raili Riikonen

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  1. Raili Riikonen
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Riikonen, R. Update to guidelines on treatment of infantile spasms. Nat Rev Neurol 8, 480–482 (2012). https://doi.org/10.1038/nrneurol.2012.157

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