A biomarker of disease burden in amyotrophic lateral sclerosis (ALS) is lacking. Now, Tortelli et al. have shown that cerebrospinal fluid levels of neurofilament light chain (NFL) are inversely correlated with diagnostic delay and functional status, and positively correlated with progression rate. NFL levels could, therefore, represent a useful marker of disease activity and progression in ALS.
ORIGINAL RESEARCH PAPER
Tortelli, R. et al. Elevated cerebrospinal fluid neurofilament light levels in patients with amyotrophic lateral sclerosis: a possible marker of disease severity and progression. Eur. J. Neurol. doi:10.1111/j.1468-1331.2012.03777.x
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Neurofilament light chain as a biomarker of ALS. Nat Rev Neurol 8, 413 (2012). https://doi.org/10.1038/nrneurol.2012.141
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DOI: https://doi.org/10.1038/nrneurol.2012.141
