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Epilepsy

HLA alleles linked to carbamazepine hypersensitivity

Nature Reviews Neurology volume 7, pages 365–366 (2011)Cite this article

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Human leukocyte antigen (HLA) screening could identify patients at risk of adverse reactions to carbamazepine, one of the most commonly used anticonvulsants. A European genome-wide association study revealed strong correlations between HLA-A*3101 and carbamazepine hypersensitivity. In Taiwan, HLA-B*1502 screening led to significant reductions in the incidence of carbamazepine-induced adverse events.

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References

  1. Shorvon, S. D. Drug treatment of epilepsy in the century of the ILAE: the second 50 years, 1959–2009. Epilepsia 50 (Suppl. 3), 93–130 (2009).

    Article  Google Scholar 

  2. Lonjou, C. et al. A marker for Stevens–Johnson syndrome: ethnicity matters. Pharmacogenomics J. 6, 265–268 (2006).

    Article  CAS  Google Scholar 

  3. Zaccara, G. et al. Idiosyncratic adverse reactions to antiepileptic drugs. Epilepsia 48, 1223–1244 (2007).

    Article  CAS  Google Scholar 

  4. McCormack, M. et al. HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N. Engl. J. Med. 364, 1134–1143 (2011).

    Article  CAS  Google Scholar 

  5. Chen, P. et al. Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan. N. Engl. J. Med. 364, 1126–1133 (2011).

    Article  CAS  Google Scholar 

  6. Hung., S. I. et al. Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. Pharmacogenet. Genomics 16, 297–306 (2006).

    Article  CAS  Google Scholar 

  7. Ozeki, T. et al. Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population. Hum. Mol. Genet. 20, 1034–1041 (2011).

    Article  CAS  Google Scholar 

  8. Einarson, T. R. Drug-related hospital admissions. Ann. Pharmacother. 27, 832–840 (1993).

    Article  CAS  Google Scholar 

  9. Loscher, W. et al. The clinical impact of pharmacogenetics on the treatment of epilepsy. Epilepsia 50, 1–23 (2009).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Muscular and Neurodegenerative Disease Unit, University of Genoa, G. Gaslini Institute, Largo Gaslini 5, Genoa, 16147, Italy

    Pasquale Striano & Federico Zara

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  1. Pasquale Striano
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  2. Federico Zara
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Correspondence to Pasquale Striano.

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The authors declare no competing financial interests.

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Striano, P., Zara, F. HLA alleles linked to carbamazepine hypersensitivity. Nat Rev Neurol 7, 365–366 (2011). https://doi.org/10.1038/nrneurol.2011.90

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