Neurological markers are used to predict outcomes in patients resuscitated after cardiac arrest, and are crucial in informing treatment decisions in comatose patients. A multicenter study reports that therapeutic hypothermia in cardiac arrest alters the reliability of several recommended prognostic parameters, and the authors highlight challenges to optimization of prognostic paradigms.
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References
Geocadin, R. G. et al. Neurologic prognosis and withdrawal of life support after resuscitation from cardiac arrest. Neurology 67, 105–108 (2006).
Bernard, S. A. et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N. Engl. J. Med. 346, 557–563 (2002).
Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N. Engl. J. Med. 346, 549–556 (2002).
Peberdy, M. A. et al. Part 9: post-cardiac arrest care: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 122 (18 Suppl. 3), S768–S786 (2010).
Bouwes, A. et al. Prognosis of coma after therapeutic hypothermia: a prospective cohort study. Ann. Neurol. http://dx.doi.org/10.1002/ana.22632.
Fugate, J. E. et al. Predictors of neurologic outcome in hypothermia after cardiac arrest. Ann. Neurol. 68, 907–914 (2010).
Rossetti, A. O., Oddo, M., Logroscino, G. & Kaplan, P. W. Prognostication after cardiac arrest and hypothermia: a prospective study. Ann Neurol. 67, 301–307 (2010).
Wijdicks, E. F., Hijdra, A., Young, G. B., Bassetti, C. L. & Wiebe, S. Practice parameter: prediction of outcome in comatose survivors after cardiopulmonary resuscitation (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 67, 203–210 (2006).
Neumar, R. W. et al. Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council. Circulation 118, 2452–2483 (2008).
Peberdy, M. A. et al. Cardiopulmonary resuscitation of adults in the hospital: a report of 14720 cardiac arrests from the National Registry of Cardiopulmonary Resuscitation. Resuscitation 58, 297–308 (2003).
Acknowledgements
R. G. Geocadin is supported in part by NIH grant RO1-HL071568.
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Geocadin, R., Kaplan, P. The effect of therapeutic hypothermia on prognostication. Nat Rev Neurol 8, 5–6 (2012). https://doi.org/10.1038/nrneurol.2011.201
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DOI: https://doi.org/10.1038/nrneurol.2011.201