A large, retrospective analysis of patients with amyotrophic lateral sclerosis (ALS) and progressive muscular atrophy (PMA) indicates that a substantial proportion of PMA patients develop upper motor neuron signs indicative of an ALS diagnosis. The findings suggest that PMA should be considered as part of the ALS spectrum rather than as a distinct entity.
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Maragakis, N. Progressive muscular atrophy in the ALS spectrum. Nat Rev Neurol 6, 187–188 (2010). https://doi.org/10.1038/nrneurol.2010.29
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DOI: https://doi.org/10.1038/nrneurol.2010.29