Mutations in six genes have been unequivocally linked to Parkinson disease (PD). A recent study found that among 953 patients with the early-onset form of PD, ≈17% harbored a mutation in one of these genes. This finding raises important issues concerning genetic testing and genetic counseling for early-onset PD.
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Acknowledgements
C. Klein is a recipient of a career development award from the Volkswagen Foundation and the Hermann and Lilly Schilling Foundation. A. Djarmati acknowledges research support from the German Research Foundation (grant number DJ 65/4–1).
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Supplementary Figure 1
Countries where mutation frequency data are available for the six genes associated with Parkinson disease. (DOC 3307 kb)
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Klein, C., Djarmati, A. Genetic testing in Parkinson disease—who should be assessed?. Nat Rev Neurol 7, 7–9 (2011). https://doi.org/10.1038/nrneurol.2010.197
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DOI: https://doi.org/10.1038/nrneurol.2010.197
