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Alzheimer disease

Clinical use of cholinergic drugs in Alzheimer disease

Drugs acting on the cholinergic system can improve or worsen cognitive abilities, and their effects are particularly pronounced in frail elderly individuals and patients with Alzheimer disease. Guidelines are urgently needed on the judicious use of cholinergic drugs.

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References

  1. Gardette, V. et al. Predictive factors of discontinuation and switch of cholinesterase inhibitors in community-dwelling patients with Alzheimer's disease: a 2-year prospective, multicentre, cohort study. CNS Drugs 24, 431–442 (2010).

    Article  CAS  Google Scholar 

  2. Burns, A. et al. Clinical practice with anti-dementia drugs: a consensus statement from British Association for Psychopharmacology. J. Psychopharmacol. 20, 732–755 (2006).

    Article  CAS  Google Scholar 

  3. Rodda, J. & Walker, Z. Ten years of cholinesterase inhibitors. Int. J. Geriatr. Psychiatry 24, 437–442 (2009).

    Article  Google Scholar 

  4. Herrmann, N. et al. A population-based study of cholinesterase inhibitor use for dementia. J. Am. Geriatr. Soc. 55, 1517–1523 (2007).

    Article  Google Scholar 

  5. Kogut, S. J., El-Maouche, D. & Abughosh, S. M. Decreased persistence to cholinesterase inhibitor therapy with concomitant use of drugs that can impair cognition. Pharmacotherapy 25, 1729–1735 (2005).

    Article  CAS  Google Scholar 

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Correspondence to Serge Gauthier.

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The authors declare no competing financial interests.

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Desmarais, J., Gauthier, S. Clinical use of cholinergic drugs in Alzheimer disease. Nat Rev Neurol 6, 418–420 (2010). https://doi.org/10.1038/nrneurol.2010.105

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