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Pain

Do ACE inhibitors exacerbate complex regional pain syndrome?

Nature Reviews Neurology volume 5, pages 306–308 (2009)Cite this article

Complex regional pain syndrome is a chronic condition arising mainly after tissue injury and involves both inflammatory and neurogenic factors. Use of angiotensin-converting-enzyme inhibitors has been associated with an increased risk of developing the chronic pain condition, which suggests possible roles for substance P and bradykinin in the underlying pathogenic process.

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Authors and Affiliations

  1. Department of Psychiatry, P.A.I.N. group, McLean Hospital, Belmont, MA, USA

    David Borsook

  2. Department of Radiology, P.A.I.N. Group, Children's Hospital Boston, Boston, MA, USA

    Simona Sava

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  1. David Borsook
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  2. Simona Sava
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Correspondence to David Borsook.

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Borsook, D., Sava, S. Do ACE inhibitors exacerbate complex regional pain syndrome?. Nat Rev Neurol 5, 306–308 (2009). https://doi.org/10.1038/nrneurol.2009.73

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