MRI provides a very sensitive reflection of the histopathological changes in multiple sclerosis. Many short-term studies fail to appreciate the relationship between MRI and clinical findings, although such shortcomings might be argued to reflect a weakness of clinical measures, rather than of MRI.
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Barkhof, F., Filippi, M. MRI—the perfect surrogate marker for multiple sclerosis?. Nat Rev Neurol 5, 182–183 (2009). https://doi.org/10.1038/nrneurol.2009.31
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DOI: https://doi.org/10.1038/nrneurol.2009.31
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