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Glomerular disease

Crescentic glomerulonephritis: beyond the immune system

Nature Reviews Nephrology volume 13, pages 198–200 (2017)Cite this article

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T cells mediate injury in glomerulonephritis but mice devoid of T cells and B cells can also develop this disease. A new study shows that expression of the cytokine receptor common subunit γ and IL-15 in podocytes protects against crescentic glomerulonephritis, independent of B cells, T cells and natural killer cells.

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Figure 1: Immune status and cytokine receptor common subunit γ (γc) expression levels in different strains of mice with nephrotoxic nephritis.

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  1. Department of Medicine, Philip Webster and Charles Pusey are at Imperial College London, Hammersmith Hospital Campus, Du Cane Road, W12 0NN, London.,

    Philip Webster & Charles Pusey

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  1. Philip Webster
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  2. Charles Pusey
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Correspondence to Charles Pusey.

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The authors declare no competing financial interests.

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Webster, P., Pusey, C. Crescentic glomerulonephritis: beyond the immune system. Nat Rev Nephrol 13, 198–200 (2017). https://doi.org/10.1038/nrneph.2017.32

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