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Treatment of HCV-infected patients with advanced kidney disease

Nature Reviews Nephrology volume 14, pages 6–8 (2018)Cite this article

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Antiviral treatment options for HCV-infected patients with advanced kidney disease are limited because few clinical trials have tested the efficacy of antiviral drugs in this population. Now, a phase III trial of two pan-genotypic drugs demonstrates excellent viral clearance with minimal adverse events in HCV-infected patients with advanced kidney disease.

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References

  1. Ladino, M., Pedraza, F. & Roth, D. Hepatitis C virus infection in chronic kidney disease. J. Am. Soc. Nephrol. 27, 2238–2246 (2016).

    Article  CAS  Google Scholar 

  2. Fabrizi, F., Dixit, V. & Messa, P. Impact of hepatitis C on survival in dialysis patients: a link with cardiovascular mortality? J. Viral Hepat. 19, 601–617 (2012).

    Article  CAS  Google Scholar 

  3. Molnar, M. Z. et al. Association of hepatitis C viral infection with incidence and progression of chronic kidney disease in a large cohort of US veterans. Hepatology 61, 1495–1502 (2015).

    Article  CAS  Google Scholar 

  4. Goodkin, D. A. et al. Mortality, hospitalization, and quality of life among patients with hepatitis C infection on hemodialysis. Clin. J. Am. Soc. Nephrol. 12, 287–297 (2017).

    Article  Google Scholar 

  5. Gane, E. et al. Glecaprevir and pibrentasvir in patients with HCV and severe renal impairment. N. Engl. J. Med. 377, 1448–1455 (2017).

    Article  CAS  Google Scholar 

  6. Saxena, V. et al. Safety and efficacy of sofosbuvir-containing regimens in hepatitis C-infected patients with impaired renal function. Liver Int. 36, 807–816 (2016).

    Article  CAS  Google Scholar 

  7. Roth, D. et al. Grazoprevir plus elbasvir in treatment-naive and treatment-experienced patients with hepatitis C virus genotype 1 infection and stage 4–5 chronic kidney disease (the C-SURFER study): a combination phase 3 study. Lancet 386, 1537–1545 (2015).

    Article  CAS  Google Scholar 

  8. Pockros, P. J. et al. Efficacy of direct-acting antiviral combination for patients with hepatitis C virus genotype 1 infection and severe renal impairment or end-stage renal disease. Gastroenterology 150, 1590–1598 (2016).

    Article  CAS  Google Scholar 

  9. Gane, E. et al. in AASLD The Liver Meeting abstract 935 (Boston, 2016).

    Google Scholar 

  10. Rodriguez, C. V. et al. in AASLD The Liver Meeting abstract 1946 (Boston, 2016).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Katz Family Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, 1120 NW 14th Street, Miami, Florida 33136, USA,

    Marco Ladino

  2. at The Miami Veterans Administration Medical Center, 1201 NW 16th Street, Miami, Florida 33125, USA.,

    Marco Ladino

  3. Katz Family Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, 1120 NW 14th Street, Miami, 33136, Florida, USA

    David Roth

Authors
  1. Marco Ladino
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  2. David Roth
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Corresponding author

Correspondence to David Roth.

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Competing interests

M.L. declares no competing interests. D.R. is a consultant and is on the Scientific Advisory Boards for Merck & Co. and AbbVie.

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Ladino, M., Roth, D. Treatment of HCV-infected patients with advanced kidney disease. Nat Rev Nephrol 14, 6–8 (2018). https://doi.org/10.1038/nrneph.2017.161

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