New data indicate a long-term beneficial effect of reduced sodium intake on mortality. Among the participants of the phase I (n = 744) and phase II (n = 2,382) TOHP sodium reduction trials, the risk of death during a median post-trial period of 24 years was 15% lower in the intervention group than in the control group. The analysis showed a direct linear relationship between average sodium intake and total mortality, even at the lowest sodium levels. The TOHP trials used well-characterized measures of sodium intake estimated from urinary sodium excretion.
References
Cook, N. R. et al. Sodium intake and all-cause mortality over 20 years in the trials of hypertension prevention. J. Am. Coll. Cardiol. 68, 1609–1617 (2016)
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Carney, E. Relationship between sodium intake and mortality. Nat Rev Nephrol 12, 715 (2016). https://doi.org/10.1038/nrneph.2016.154
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DOI: https://doi.org/10.1038/nrneph.2016.154
