Phospholipase A2 (PLA2) ameliorates cisplatin-induced acute kidney injury by modulating inflammatory responses, say researchers. Kim et al. found that administration of PLA2 to mice increased the population of T regulatory cells and secretion of IL-10 in the kidney. Importantly, the anticancer effects of cisplatin were not affected by PLA2 treatment in a tumour-bearing model.
References
Kim, H. et al. Phospholipase A2 inhibits cisplatin-induced acute kidney injury by modulating regulatory T cells by the CD206 mannose receptor. Kidney Int. 10.1038/ki.2015.147
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PLA2 and cisplatin-induced acute kidney injury. Nat Rev Nephrol 11, 386 (2015). https://doi.org/10.1038/nrneph.2015.93
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DOI: https://doi.org/10.1038/nrneph.2015.93
