Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Glomerular disease

Efficacy of corticosteroids in high-risk IgA nephropathy

Nature Reviews Nephrology volume 11, pages 319–320 (2015)Cite this article

Subjects

Corticosteroids are frequently used to treat patients with IgA nephropathy (IgAN) despite a paucity of data to support their use in individuals with substantially reduced renal function. A retrospective study provides evidence that these agents may slow the rate of decline in renal function in high-risk patients with IgAN.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Kidney Disease: Improving Global Outcomes (KDIGO) Glomerulonephritis Work Group. KDIGO Clinical Practice Guideline for Glomerulonephritis. Kidney Int. Suppl. 2, 139–274 (2012).

  2. Tesar, V. et al. Corticosteroids in IgA nephropathy: a retrospective analysis from the VALIGA study. J. Am. Soc. Nephrol. http://dx.doi.org/10.1681/ASN.2014070697.

  3. Floege, J. & Feehally, J. Treatment of IgA nephropathy and Henoch-Schonlein nephritis. Nat. Rev. Nephrol. 9, 320–327 (2013).

    Article  CAS  Google Scholar 

  4. Eitner, F., Ackermann, D., Hilgers, R. D. & Floege, J. Supportive versus immunosuppressive therapy of progressive IgA nephropathy (STOP) IgAN trial: rationale and study protocol. J. Nephrol. 21, 284–289 (2008).

    CAS  PubMed  Google Scholar 

  5. Pozzi, C. et al. Corticosteroid effectiveness in IgA nephropathy: long-term results of a randomized, controlled trial. J. Am. Soc. Nephrol. 15, 157–163 (2004).

    Article  CAS  Google Scholar 

  6. Smerud, H. K. et al. New treatment for IgA nephropathy: enteric budesonide targeted to the ileocecal region ameliorates proteinuria. Nephrol. Dial. Transplant. 26, 3237–3242 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Nephrology and Immunology, Rheinisch-Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, Aachen, 52074, Germany

    Jürgen Floege

Authors
  1. Jürgen Floege
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jürgen Floege.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Floege, J. Efficacy of corticosteroids in high-risk IgA nephropathy. Nat Rev Nephrol 11, 319–320 (2015). https://doi.org/10.1038/nrneph.2015.47

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneph.2015.47

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing