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Immune regulation of kidney disease in 2015

Updates on immunosuppression in kidney disease

Numerous studies in 2015 focused on therapeutic immune modulation and immunosuppression. Trials of budenoside in patients with IgA nephropathy who are unresponsive to supportive therapy, and of low-dose IL-2 to enforce regulatory T-cell-mediated immunosuppression in autoimmune disease all produced promising results.

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Figure 1: Low-dose IL-2 therapy for autoimmune diseases.

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Acknowledgements

This work was supported by the Deutsche Forschungsgemeinschaft (grant numbers AN372/11-2, AN372/12-2, AN372/14-3, AN372/15-1, AN372/16-1, AN372/17-1).

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Correspondence to Hans-Joachim Anders.

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H-J.A. has received consultancy fees from GlaxoSmithKline, Roche, and Bayer.

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Anders, HJ. Updates on immunosuppression in kidney disease. Nat Rev Nephrol 12, 65–66 (2016). https://doi.org/10.1038/nrneph.2015.202

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