In the search for potential biomarkers to predict the success of renal sympathetic denervation in patients with resistant hypertension (n = 55), Dörr et al. measured the serum levels of key factors associated with endothelial function: fms-like tyrosine kinase-1 (sFLT-1), intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). Baseline levels of sFLT-1, ICAM-1 and VCAM-1 were all significantly higher in those who achieved a reduction in systolic blood pressure of >10 mmHg 6 months after renal sympathetic denervation (n = 46) than in nonresponders, suggesting these factors might be useful clinical biomarkers.
References
Dörr, O. et al. Soluble fms-like tyrosine kinase-1 and endothelial adhesion molecules (intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1) as predictive markers for blood pressure reduction after renal sympathetic denervation. Hypertension 10.1161/hypertensionaha.113.02266
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Predictive biomarkers identified for renal denervation. Nat Rev Nephrol 10, 182 (2014). https://doi.org/10.1038/nrneph.2014.22
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DOI: https://doi.org/10.1038/nrneph.2014.22
