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Glomerular disease

The search goes on: suPAR is not the elusive FSGS factor

Nature Reviews Nephrology volume 10, pages 431–432 (2014)Cite this article

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New research indicates that intact soluble urokinase plasminogen activator receptor (suPAR) does not induce albuminuria in mice. These data corroborate the most recent clinical findings, showing that intact suPAR is not the plasma permeability factor responsible for recurrence of focal segmental glomerulosclerosis after renal transplantation.

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References

  1. Deegens, J. K. & Wetzels, J. F. Immunosuppressive treatment of focal segmental glomerulosclerosis: lessons from a randomized controlled trial. Kidney Int. 80, 798–801 (2011).

    Article  CAS  Google Scholar 

  2. Maas, R. J., Deegens, J. K. & Wetzels, J. F. Serum suPAR in patients with FSGS: trash or treasure? Paediatr. Nephrol. 28, 1041–1048 (2013).

    Article  Google Scholar 

  3. Cathelin, D. et al. Administration of recombinant soluble urokinase receptor per se is not sufficient to induce podocyte alterations and proteinuria in mice. J. Am. Soc. Nephrol. http://dx.doi.org/10.1681/ASN.2013040425.

  4. Rea, R., Smith, C., Sandhu, K., Kwan, J. & Tomson, C. Successful transplant of a kidney with focal segmental glomerulosclerosis. Nephrol. Dial. Transplant. 16, 416–417 (2001).

    Article  CAS  Google Scholar 

  5. McCarthy, E. T., Sharma, M. & Savin, V. J. Circulating permeability factors in idiopathic nephrotic syndrome and focal segmental glomerulosclerosis. Clin. J. Am. Soc. Nephrol. 5, 2115–2121 (2010).

    Article  PubMed  Google Scholar 

  6. Wei, C. et al. Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis. Nat. Med. 17, 952–960 (2011).

    Article  CAS  PubMed  Google Scholar 

  7. Wei, C. et al. Modification of kidney barrier function by the urokinase receptor. Nat. Med. 14, 55–63 (2008).

    Article  CAS  PubMed  Google Scholar 

  8. Schlondorff, D. Are serum suPAR determinations by current ELISA methodology reliable diagnostic biomarkers for FSGS? Kidney Int. 85, 499–501 (2014).

    Article  CAS  Google Scholar 

  9. Meijers, B. et al. The soluble urokinase receptor is not a clinical marker for focal segmental glomerulosclerosis. Kidney Int. 85, 636–640 (2014).

    Article  CAS  Google Scholar 

  10. Bock, M. E., Price, H. E., Gallon, L. & Langman, C. B. Serum soluble urokinase-type plasminogen activator receptor levels and idiopathic FSGS in children: a single-centre report. Clin. J. Am.Soc. Nephrol. 8, 1304–1311 (2013).

    Article  CAS  PubMed  Google Scholar 

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  1. Department of Nephrology, Radboud University Medical Centre, PO Box 9101, Nijmegen, 6500, HB, Netherlands

    Jeroen K. Deegens & Jack F. Wetzels

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  1. Jeroen K. Deegens
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  2. Jack F. Wetzels
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Correspondence to Jack F. Wetzels.

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The authors declare no competing financial interests.

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Deegens, J., Wetzels, J. The search goes on: suPAR is not the elusive FSGS factor. Nat Rev Nephrol 10, 431–432 (2014). https://doi.org/10.1038/nrneph.2014.113

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