O'Leary et al. report that the presence of anti-HLA antibodies at the time of simultaneous liver–kidney transplantation is associated with allograft dysfunction and shortened organ and patient survival. Preformed class I alloantibodies were eliminated after transplantation, whereas class II donor-specific antibodies persisted and were associated with poor outcomes.
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Singer, A., Segev, D. Alloantibodies in simultaneous liver–kidney transplantation. Nat Rev Nephrol 9, 373–374 (2013). https://doi.org/10.1038/nrneph.2013.84
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DOI: https://doi.org/10.1038/nrneph.2013.84
