A recent study reports that the combination of an angiotensin-receptor blocker (ARB) and a calcium-channel blocker (versus a high-dose ARB) is associated with improved blood pressure control and reduced cardiovascular, cerebrovascular and heart failure events in an elderly chronic kidney disease population. This finding raises the possibility of using fixed-dose drug combinations to improve efficacy and compliance of antihypertensive medications.
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Acknowledgements
J. R. Sowers' work is supported by NIH (R01 HL73101-08 and R01 HL107910-03) and the Veterans Affairs Merit System 0018. The authors would like to thank B. Hunter (Administrative Assistant, University of Missouri) for editorial assistance.
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Supplementary Table 1
Selected studies involving CCBs in elderly patients (DOC 48 kb)
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Nistala, R., Sowers, J. Synergy of antihypertensives in elderly patients with CKD. Nat Rev Nephrol 9, 13–15 (2013). https://doi.org/10.1038/nrneph.2012.264
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DOI: https://doi.org/10.1038/nrneph.2012.264
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