In a new study, Porcheray et al. provide evidence that a single antibody generated by alloimmunization can recognize multiple antigens in a paradigm-changing fashion. Although these results require confirmation, the presence of polyreactive antibody may offer an explanation as to why some patients with a single sensitizing event develop a wide breadth of panel-reactive antibody.
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Montgomery, R., Zachary, A. All for one and one for all—alloimmunization and polyreactivity. Nat Rev Nephrol 8, 442–443 (2012). https://doi.org/10.1038/nrneph.2012.140
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DOI: https://doi.org/10.1038/nrneph.2012.140
