Hypertension mediated by tacrolimus is largely caused by activation of the renal sodium chloride cotransporter (NCC), say researchers. In wild-type mice, tacrolimus caused salt-sensitive hypertension and increased levels of phosphorylated NCC, whereas in NCC-knockout mice, it did not affect blood pressure. The hypertensive response to tacrolimus was increased In NCC-overexpressing mice. NCC-blocking drugs reversed tacrolimus-induced hypertension in mice and increased fractional chloride excretion in human renal transplant recipients.
ORIGINAL RESEARCH PAPER
Hoorn, E. J. et al. The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension. Nat. Med. 17, 1304–1309
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How do calcineurin inhibitors cause hypertension?. Nat Rev Nephrol 7, 677 (2011). https://doi.org/10.1038/nrneph.2011.165
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DOI: https://doi.org/10.1038/nrneph.2011.165