A number of concerns have prevented the widespread use of pediatric en bloc kidneys for transplantation in adults. New evidence suggests that some of these concerns could be unfounded and that en bloc pediatric kidneys might perform as well, or even better, than grafts from traditional donors.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Salvatierra, O. et al. Successful transplantation of adult-sized kidneys into infants requires maintenance of high aortic blood flow. Transplantation 66, 819–823 (1998).
Thomusch, O., Tittelbach-Helmrich, D., Meyer, S., Drognitz, O. & Pisarski, P. Twenty-year graft survival and graft function analysis by a matched pair study between pediatric en bloc kidney and deceased adult donor grafts. Transplantation 88, 920–925 (2009).
Sureshkumar, K. K., Reddy, C. S., Nghiem, D. D., Sandroni, S. E. & Carpenter, B. J. Superiority of pediatric en bloc renal allografts over living donor kidneys: a long-term functional study. Transplantation 82, 348–353 (2006).
Hobart, M. G. et al. Transplantation of pediatric en bloc cadaver kidneys into adult recipients. Transplantation 66, 1689–1694 (1998).
Terasaki, P. I., Koyama, H., Cecka, J. M. & Gjertson, D. W. The hyperfiltration hypothesis in human renal transplantation. Transplantation 57, 1450–1454 (1994).
Abitol, C. L. & Ingelfinger, J. R. Nephron mass and cardiovascular and renal disease risks. Semin. Nephrol. 29, 445–454 (2009).
Marañes, A. et al. Functional glomerular reserve in recipients of en bloc pediatric transplant kidneys. Transplantation 65, 677–680 (1998).
Alfrey, E. J., Boissy, A. R. & Lerner, S. M. Dual-kidney transplants: long-term results. Transplantation 75, 1232–1236 (2003).
Ojo, A. O. et al. Survival in recipients of marginal cadaveric donor kidneys compared with other recipients and wait-listed transplant candidates. J. Am. Soc. Nephrol. 12, 589–597 (2001).
Lee, C. M. et al. The kidneys that nobody wanted: support for the utilization of expanded criteria donors. Transplantation 62, 1832–1841 (1996).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Alfrey, E., Hwang, C. Pediatric en bloc kidneys are suitable for adult recipients. Nat Rev Nephrol 6, 73–74 (2010). https://doi.org/10.1038/nrneph.2009.227
Issue Date:
DOI: https://doi.org/10.1038/nrneph.2009.227
