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Transplantation

ABO-incompatible renal transplants: time for increased use?

Use of ABO-incompatible renal transplants from living donors has proven a viable and practical transplantation strategy. The protocols devised through the Johns Hopkins Incompatible Kidney Transplant Program could result in the most rapid escalation of access to organs in the modern era of transplantation.

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References

  1. Montgomery, R. A. et al. ABO incompatible renal transplantation: a paradigm ready for broad implementation. Transplantation 87, 1246–1255 (2009).

    Article  Google Scholar 

  2. Liem, Y. S. & Weimar, W. Early living-donor kidney transplantation: a review of the associated survival benefit. Transplantation 87, 317–318 (2009).

    Article  Google Scholar 

  3. US Department of Health & Human Services OPTN: Organ Procurement Transplantation Network [online], (2009).

  4. Alexandre, G. P. et al. Present experience in a series of 26 ABO-incompatible living donor renal allografts. Transplant. Proc. 19, 4538–4342 (1987).

    CAS  PubMed  Google Scholar 

  5. Tanabe, K. et al. Long-term results of ABO-incompatible living kidney transplantation: a single center experience. Transplantation 65, 224–228 (1998).

    Article  CAS  Google Scholar 

  6. Toki, D. et al. Acute antibody-mediated rejection in living ABO-incompatible kidney transplantation: long-term impact and risk factors. Am. J. Transplant. 9, 567–577 (2009).

    Article  CAS  Google Scholar 

  7. Genberg, H., Kumlien, G., Wennberg, L., Berg, U. & Tydén, G. ABO-incompatible kidney transplantation using antigen-specific immunoadsorption and rituximab: a 3-year follow-up. Transplantation 85, 1745–1754 (2008).

    Article  CAS  Google Scholar 

  8. Allen, G. et al. Rapid accommodation of an A1 renal allograft after preconditioning for ABO-incompatible transplantation. Contrib. Nephrol. 162, 35–46 (2009).

    Article  Google Scholar 

  9. Rees, M. A. et al. A nonsimultaneous, extended, altruistic-donor chain. N. Engl. J. Med. 360, 1096–1101 (2009).

    Article  CAS  Google Scholar 

  10. Stgall, M. et al. Prevention of acute humoral rejection with C5 inhibition [abstract 178]. Am. J. Transplant. 9 (Suppl. 2), 241 (2009).

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Correspondence to Stanley C. Jordan.

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Competing interests

The author declares associations with Bristol–Myers Squibb and Talecris Biotherapeutics as consultant and recipient of grant/research support and Pfizer as recipient of grant/research support. The author also holds US Patent 6,171,585 B1.

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Jordan, S. ABO-incompatible renal transplants: time for increased use?. Nat Rev Nephrol 5, 491–492 (2009). https://doi.org/10.1038/nrneph.2009.131

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