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Plant virology

Sign turns yellow for Y-sat-infected tobacco

Nature Reviews Microbiology volume 9, pages 482–483 (2011)Cite this article

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Satellite RNAs are small subviral RNAs that depend on an associated virus (cucumber mosiac virus (CMV) for Y-sat) for their replication in a host. Although they are normally non-protein-coding, they can dramatically modify disease symptoms in a species-specific manner; for example, Y-sat induces yellowing of only some Nicotiana species. The disease-causing region of Y-sat had previously been mapped to a region known as the yellow-inducing domain; it had been suggested that this encodes an siRNA but, prior to these reports, there was no direct evidence for the involvement of siRNAs, and the identity of the host target genes was unknown.

siRNAs derived from viral satellite RNAs can downregulate host genes

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ORIGINAL RESEARCH PAPERS

  1. Shimura, H. et al. A viral satellite RNA induces yellow symptoms on tobacco by targeting a gene involved in chlorophyll biosynthesis using the RNA silencing machinery. PLoS Pathog. 7, e1002021 (2011)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Smith, N. A., Eamens, A. L. & Wang, M. B. Viral small interfering RNAs target host genes to mediate disease symptoms in plants. PLoS Pathog. 7, e1002022 (2011)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors
  1. Joanna E. Huddleston
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Huddleston, J. Sign turns yellow for Y-sat-infected tobacco. Nat Rev Microbiol 9, 482–483 (2011). https://doi.org/10.1038/nrmicro2600

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