Abstract
During the past decade, evolutionarily conserved microRNAs (miRNAs) have been characterized as regulators of almost every cellular process and signalling pathway. There is now emerging evidence that this new class of regulators also impinges on the DNA damage response (DDR). Both miRNAs and other small non-coding RNAs (ncRNAs) are induced at DNA breaks and mediate the repair process. These intriguing observations raise the possibility that crosstalk between ncRNAs and the DDR might provide a means of efficient and accurate DNA repair and facilitate the maintenance of genomic stability.
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Acknowledgements
D.C. is supported by the National Cancer Institute (NCI) (R01CA142698), the National Institute of Allergy and Infectious Diseases (NIAID) (R01 AI101897-01), a Basic Scholar Grant (ACS), the Ann-Fuller Foundation and start-up funds from the Dana-Farber Cancer Institute (DFCI). M.E.B. is supported by a fellowship from the Fonds de la Recherche en Santé du Québec (FRSQ). The authors apologize to their colleagues whose work could not be discussed owing to space constraints.
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Chowdhury, D., Choi, Y. & Brault, M. Charity begins at home: non-coding RNA functions in DNA repair. Nat Rev Mol Cell Biol 14, 181–189 (2013). https://doi.org/10.1038/nrm3523
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DOI: https://doi.org/10.1038/nrm3523
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